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Introduction of 1006036-87-8 :
MK-2894 is a highly potent and selective second generation EP4 antagonist. IC50 value: Target: EP4 MK-2894 exhibits favorable pharmacokinetic profile in a number of preclinical species and potent anti-inflammatory activity in several animal models of pain/inflammation. MK-2894 also shows favorable GI tolerability profile in rats when compared to traditional NSAID indomethacin.