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1020399-49-8 | CARM1-IN-1

CARM1-IN-1 NLT 98%

SKU : MC502412

CAS Number : 1020399-49-8

Molecular Formula : C26H21Br2NO3 | Molecular Weight : 555.26

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Purity NLT 98%
Storage at 20ºC 2 years

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Chemical Name CARM1-IN-1
CAS Number 1020399-49-8
Molecular Formula C26H21Br2NO3
Molecular Weight 555.26
Introduction of 1020399-49-8 :

CARM1-IN-1 is a potent and specific CARM1(Coactivator-associated arginine methyltransferase 1) inhibitor with IC50 of 8.6 uM; shows very low activity against PRMT1 and SET7(IC50 > 600 uM). IC50 value: 8.6 uM [1] Target: CRAM1 inhibitor in vitro: CARM1-IN-1(Cmp 7g) displayed high and selective CARM1 inhibition, with lower or no activity against a panel of different PRMTs or HKMTs. In human LNCaP cells, 7g showed a significant dose-dependent reduction of the PSA promoter activity.

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