PGS-IN-1 NLT 98%
SKU : MC502612
CAS Number : 102271-49-8
Molecular Formula : C19H26O3 | Molecular Weight : 302.41
Synonyms : KME-4;alpha-(3,5-Di-tert-Butyl-4-hydroxybenzylidene)gamma-butyrolactone
Quote Request| Purity | NLT 98% |
|---|---|
| Storage | at 20ºC 2 years |
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| Chemical Name | PGS-IN-1 |
|---|---|
| CAS Number | 102271-49-8 |
| Molecular Formula | C19H26O3 |
| Molecular Weight | 302.41 |
| Synonyms | KME-4;alpha-(3,5-Di-tert-Butyl-4-hydroxybenzylidene)gamma-butyrolactone |
PGS-IN-1 is a potent inhibitor of prostaglandin synthetase (PGS) with an IC50 of 0.28 μM; also inhibits 5-lipoxygenase with an IC50 of 1.05 μM. IC50 & Target: IC50: 0.28 μM (PGS), 1.05 μM (5-lipoxygenase)[1] In Vitro: The synthesized α-benzulidene-γ-butyrolactones are pure isomers (either cis or trans). PGS-IN-1 is the trans isomer. PGS-IN-1 exhibits potent antiinflammatrory and PGS inhibitory activity (IC50=0.28 μM). PGS-IN-1 also shows potent inhibitory activity against 5-lipoxygenase (IC50=1.05 μM)[1].
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