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103213-49-6 | [Glu1]-Fibrinopeptide B

[Glu1]-Fibrinopeptide B NLT 98%

SKU : MC503243

CAS Number : 103213-49-6

Molecular Formula : C66H95N19O26 | Molecular Weight : 1570.57

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Purity NLT 98%
Storage at 20ºC 2 years

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Chemical Name [Glu1]-Fibrinopeptide B
CAS Number 103213-49-6
MDL Number MFCD00076440
Molecular Formula C66H95N19O26
Molecular Weight 1570.57
Introduction of 103213-49-6 :

[Glu1]-Fibrinopeptide B is derived from fibrinopeptide B amino acid residues 1-14. Human fibrinopeptide B (hFpB), a thrombin-derived proteolytic cleavage product of the fibrinogen B beta-chain, to stimulate neutrophils (PMN), monocytes, and fibroblasts. In Vitro: hFpB causes directed cell migration of PMN and fibroblasts that is optimal at approximately 10 nM. hFpB causes a rapid, dose-dependent increase in PMN cytoskeletal associated actin, but unlike fMLP, hFpB does not cause PMN aggregation, release of lysosomal enzymes (lysozyme and beta-glucuronidase), or the production of superoxide anion. These results suggest that hFpB may have a role in recruiting PMN and fibroblasts at sites of fibrin deposition and turnover. The capacity of hFpB to cause PMN chemotaxis without causing concurrent release of lysosomal enzymes or the production of superoxide anion is further evidence for the complexity of PMN responses to chemotactic agents[1].

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