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103766-25-2 | Gimeracil

Gimeracil NLT 98%

SKU : MC503561

CAS Number : 103766-25-2

Molecular Formula : C5H4ClNO2 | Molecular Weight : 145.54

Synonyms : Gimestat

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Purity NLT 98%
Storage at 20ºC 2 years

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Chemical Name Gimeracil
CAS Number 103766-25-2
MDL Number MFCD00923843
Molecular Formula C5H4ClNO2
Molecular Weight 145.54
Synonyms Gimestat
Introduction of 103766-25-2 :

Gimeracil(Gimestat) is an inhibitor of dihydropyrimidine dehydrogenase (DPYD), which degrades pyrimidine including 5-fluorouracil in the blood; inhibits homologous recombination. IC50 Value: Target: DPYD in vitro: Gimeracil had radiosensitizing effects by partially inhibiting homologous recombination (HR) in the repair of DNA double strand breaks. Tail moments in neutral comet assay increased in gimeracil-treated cells. Gimeracil restrained the formation of foci of Rad51 and replication protein A (RPA), whereas it increased the number of foci of Nbs1, Mre11, Rad50, and FancD2. Gimeracil did not sensitize DPYD-depleted cells [1]. Gimeracil inhibited DNA DSB repair. It did not sensitize cells deficient in HR but sensitized those deficient in NHEJ. In SCneo assay, Gimeracil reduced the frequency of neo-positive clones. Additionally, it sensitized the cells in S-phase more than in G0/G1 [2]. in vivo:

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