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104012-37-5 | Tussilagone

Tussilagone NLT 98%

SKU : MC503719

CAS Number : 104012-37-5

Molecular Formula : C23H34O5 | Molecular Weight : 390.51

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Purity NLT 98%
Storage at 20ºC 2 years

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Chemical Name Tussilagone
CAS Number 104012-37-5
MDL Number MFCD01709134
Molecular Formula C23H34O5
Molecular Weight 390.51
Introduction of 104012-37-5 :

Tussilagone, a major active component in Tussilago farfara, has anti-inflammatory effect. Tussilagone ameliorates inflammatory responses in dextran sulphate sodium-induced murine colitis. Tussilagone inhibits the inflammatory response and improves survival in cecal ligation and puncture (CLP)-induced septic mice[1][2]. In Vitro: Tussilagone suppressed the expression of the inflammatory mediators, nitric oxide and prostaglandin E2, and the inflammatory cytokines, tumor necrosis factor-alpha (TNF-α) and high-mobility group box 1 (HMGB1), in lipopolysaccharide-stimulated RAW 264.7 cells and peritoneal macrophages. Tussilagone also reduced the activation of the mitogen-activated protein kinases and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) involved in the activation of various inflammatory mediators in activated macrophages[1]. In Vivo: Tussilagone administration (1 mg/kg and 10 mg/kg) produced decreased mortality and lung injury in CLP-activated septic mice. Augmented expression of cyclooxygenase (COX)-2 and TNF-α in pulmonary alveolar macrophages of septic mice were attenuated by tussilagone administration[2].

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