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104054-27-5 | Atipamezole

Atipamezole NLT 98%

SKU : MC503736

CAS Number : 104054-27-5

Molecular Formula : C14H16N2 | Molecular Weight : 212.29

Synonyms : MPV 1248

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Purity NLT 98%
Storage at 20ºC 2 years

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Chemical Name Atipamezole
CAS Number 104054-27-5
MDL Number MFCD00864502
Molecular Formula C14H16N2
Molecular Weight 212.29
Synonyms MPV 1248
Introduction of 104054-27-5 :

Atipamezole is a synthetic α2-adrenoceptor antagonist with a Ki of 1.6 nM. IC50 & Target: Ki: 1.6 nM[1] In Vitro: The affinity of atipamezole for α2-adrenoceptors and its α21 selectivity ratio are considerably higher than yohimbine. Atipamezole is not selective for subtypes of α2-adrenoceptors. It has negligible affinity for 5-HT1, 5-HT2 and I2 bindings sites[1]. In Vivo: Atipamezole is well tolerated in rodents. In anesthetized, normotensive rats, the cardiovascular effects of atipamezole (0.01–1 mg/kg, i.v.) are rather modest. Atipamezole is commonly used by veterinarians to awaken animals from sedation or anesthesia. Atipamezole increases sexual activity in rats and monkeys. In animals with sustained nociception, atipamezole increases pain-related responses by blocking the noradrenergic feedback inhibition of pain. Atipamezole at low doses has beneficial effects on alertness, selective attention, planning, learning, and recall in experimental animals, but not necessarily on short-term working memory[1].

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