SKU : MC503927
CAS Number : 10448-84-7
Molecular Formula : C27H28N2O4 | Molecular Weight : 444.52
Synonyms : CI628
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
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Chemical Name | Nitromifene |
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CAS Number | 10448-84-7 |
MDL Number | MFCD00865555 |
Molecular Formula | C27H28N2O4 |
Molecular Weight | 444.52 |
Synonyms | CI628 |
Nitromifene is an antagonist of estrogen receptor (ER). IC50 & Target: ER[1] In Vitro: Nitromifene is an antagonist of estrogen receptor (ER). At 0.5 μM and 1.0 μM concentrations, Nitromifene inhibits MCF 7 cell proliferation to 70% of that in drug-free controls. At higher concentrations, Nitromifene is clearly more effective than other metabolites. Specifically bound estradiol is displaced from intact MCF 7 cells by Nitromifene. Nitromifene is an effective antagonist of the ability of calmodulin (CM) to activate cyclic nucleotide phosphodiesterase[1].
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