SKU : MC504533
CAS Number : 105737-62-0
Molecular Formula : C23H27Cl2F3N4O5 | Molecular Weight : 567.39
Synonyms : CGP 20712 (mesylate)
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
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Chemical Name | CGP 20712 A |
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CAS Number | 105737-62-0 |
MDL Number | MFCD06798358 |
Molecular Formula | C23H27Cl2F3N4O5 |
Molecular Weight | 567.39 |
Synonyms | CGP 20712 (mesylate) |
CGP 20712 A (CGP 20712 mesylate) is a highly selective β1-adrenoceptor antagonist with an IC50 of 0.7 nM. CGP 20712 A exhibits ~10,000-fold selectivity over β2-adrenoceptors[1]. IC50 & Target: IC50: 0.7 nM (β1-adrenoceptor)[1] In Vitro: In myocytes, the activation of adenylate cyclase causes by β2-adrenoceptors is not detected in the presence of 10 nM, 100 nM or 1000 nM CGP 20712 A (CGP 20712 mesylate), which selectively antagonized beta1-adrenoceptors[2]. In Vivo: Pretreatment of 8-day-old rats with 5 mg/kg CGP 20712 A do not change the plasma ACTH response to insulin injection[3].
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