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Introduction of 10592-13-9 :
Doxycycline hydrochloride, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor. In Vitro: Doxycycline hydrochloride affects growth of glioma cells only under high concentrations. Doxycycline hydrochloride decreases MT-CO1 protein content with concentrations of 1 µg/mL and higher in SVG cells. In Vivo: Doxycycline hydrochloride (oral; 200 or 800 mg/kg/day; for 3 months) reduces active MMP-9 in untreated HT mice in a dose-dependent manner