SKU : MC504667
CAS Number : 10605-02-4
Molecular Formula : C21H22ClNO4 | Molecular Weight : 387.86
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
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Chemical Name | Palmatine (chloride) |
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CAS Number | 10605-02-4 |
MDL Number | MFCD00016656 |
Molecular Formula | C21H22ClNO4 |
Molecular Weight | 387.86 |
Palmatine chloride is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor. Palmatine chloride can ameliorate DSS-induced colitis by mitigating colonic injury, preventing gut microbiota dysbiosis, and regulating tryptophan catabolism. Palmatine has the potential for colitis treatment[1]. In Vitro: Palmatine exhibits more potent IDO-1 inhibitory activity , which IC50 on rhIDO-1 is 157 μM, and on HEK 293-hIDO-1 is 3 μM[1]. In Vivo: Palmatine (oral administration; 50 or 100 mg/kg, 7 days) has less distortion of epithelium, and fewer infiltrations of inflammatory cells, resulting in significantly lower histopathological scores, it also significantly suppresses the colonic MPO activity[1].
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