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10605-02-4 | Palmatine (chloride)

Palmatine (chloride) NLT 98%

SKU : MC504667

CAS Number : 10605-02-4

Molecular Formula : C21H22ClNO4 | Molecular Weight : 387.86

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Purity NLT 98%
Storage at 20ºC 2 years

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Chemical Name Palmatine (chloride)
CAS Number 10605-02-4
MDL Number MFCD00016656
Molecular Formula C21H22ClNO4
Molecular Weight 387.86
Introduction of 10605-02-4 :

Palmatine chloride is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor. Palmatine chloride can ameliorate DSS-induced colitis by mitigating colonic injury, preventing gut microbiota dysbiosis, and regulating tryptophan catabolism. Palmatine has the potential for colitis treatment[1]. In Vitro: Palmatine exhibits more potent IDO-1 inhibitory activity , which IC50 on rhIDO-1 is 157 μM, and on HEK 293-hIDO-1 is 3 μM[1]. In Vivo: Palmatine (oral administration; 50 or 100 mg/kg, 7 days) has less distortion of epithelium, and fewer infiltrations of inflammatory cells, resulting in significantly lower histopathological scores, it also significantly suppresses the colonic MPO activity[1].

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