Tel: +86 (0)571 8102-5280 Email:
106128-89-6 | Senktide

Senktide NLT 98%

SKU : MC504718

CAS Number : 106128-89-6

Molecular Formula : C40H55N7O11S | Molecular Weight : 841.97

Quote Request
Purity NLT 98%
Storage at 20ºC 2 years

* The above information is for reference only.

* If the product has intellectual property rights, a license granted is must or contact us.

Chemical Name Senktide
CAS Number 106128-89-6
MDL Number MFCD00076799
Molecular Formula C40H55N7O11S
Molecular Weight 841.97
Introduction of 106128-89-6 :

Senktide is a tachykinin NK3 receptor agonist. IC50 & Target: NK3 receptor[1] In Vitro: The selective NK3 receptor agonist Senktide excites 24 of 31 dopaminergic neurons in the substantia nigra pars compacta in a concentration-dependent manner. The effective concentration range is between 3 to 3000 nm. The mean EC50 for Senktide is 41.2±9 nm (n=5)[2]. In Vivo: I.c.v. injection of Senktide causes a dose-dependent increase in total distance traveled (F6,72=6.344, P<0.001). This increase reaches statistical significance compare to the vehicle-treated group at 0.06 nmol and higher. The Senktide-induced increase in locomotor activity brought about by 0.1 nmol of Senktide is significantly and dose-dependently decreased by the tachykinin NK3 receptor antagonists talnetant at 30 mg/kg and SB222200 at 30 mg/kg, but not by osanetant, when tested in parallel in a single experiment (F7,78=10.32, P<0.001), although a non-significant reduction is observed. However, when tested using another vehicle (Vitamin E and glycofurol), osanetant does decrease activity significantly compare to Senktide-treated gerbils (F2,30=10.10, P<0.001)[1].

Related Products