SKU : MC506281
CAS Number : 110368-33-7
Molecular Formula : C24H28O3 | Molecular Weight : 364.48
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
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Chemical Name | Ch55 |
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CAS Number | 110368-33-7 |
MDL Number | MFCD06798383 |
Molecular Formula | C24H28O3 |
Molecular Weight | 364.48 |
Ch55 is a potent synthetic retinoid. Ch55 binds to RAR-α and RAR-β receptors with high affinity. Ch55 displays low affinity for cellular retinoic acid binding protein (CRABP). Ch55 is a potent inducer of the differentiation of HL60 cells with an EC50 of 200 nM. Ch55 can be used for cancer research[1][2]. In Vitro: Ch55 inhibits squamous cell differentiation of rabbit tracheal epithelial cells by inhibiting type I transglutaminase activity (EC50 = 0.02 nM) and increasing cholesterol sulfate levels (EC50 = 0.03 nM). Ch55 also induce differentiation of embryonic carcinoma F9 cells and melanoma S91 cells (EC50s = 0.26 and 0.5 nM, respectively), and inhibits the induction of ornithine decarboxylase activity in 3T6 fibroblasts (EC50 = 1 nM)[1].
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