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110368-33-7 | Ch55

Ch55 NLT 98%

SKU : MC506281

CAS Number : 110368-33-7

Molecular Formula : C24H28O3 | Molecular Weight : 364.48

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Purity NLT 98%
Storage at 20ºC 2 years

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Chemical Name Ch55
CAS Number 110368-33-7
MDL Number MFCD06798383
Molecular Formula C24H28O3
Molecular Weight 364.48
Introduction of 110368-33-7 :

Ch55 is a potent synthetic retinoid. Ch55 binds to RAR-α and RAR-β receptors with high affinity. Ch55 displays low affinity for cellular retinoic acid binding protein (CRABP). Ch55 is a potent inducer of the differentiation of HL60 cells with an EC50 of 200 nM. Ch55 can be used for cancer research[1][2]. In Vitro: Ch55 inhibits squamous cell differentiation of rabbit tracheal epithelial cells by inhibiting type I transglutaminase activity (EC50 = 0.02 nM) and increasing cholesterol sulfate levels (EC50 = 0.03 nM). Ch55 also induce differentiation of embryonic carcinoma F9 cells and melanoma S91 cells (EC50s = 0.26 and 0.5 nM, respectively), and inhibits the induction of ornithine decarboxylase activity in 3T6 fibroblasts (EC50 = 1 nM)[1].

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