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1125758-85-1 | A-804598

A-804598 NLT 98%

SKU : MC507158

CAS Number : 1125758-85-1

Molecular Formula : C19H17N5 | Molecular Weight : 315.37

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Purity NLT 98%
Storage at 20ºC 2 years

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Chemical Name A-804598
CAS Number 1125758-85-1
MDL Number MFCD22683834
Molecular Formula C19H17N5
Molecular Weight 315.37
Introduction of 1125758-85-1 :

A-804598 is a CNS penetrant, competitive and selective P2X7 receptor antagonist with IC50s of 9 nM, 10 nM and 11 nM for mouse, rat and human P2X7 receptors, respectively[1]. IC50 & Target: IC50: 9 nM (mouse P2X7 receptor), 10 nM (rat P2X7 receptor), 11 nM (human P2X7 receptor)[1] In Vitro: Pre-incubation with A-804598 (0.1-10 μM; 1 hour) significantly attenuates BzATP-induced cell loss in a concentration-dependent manner. 3 μM A-804598 exhibits the greatest protective effect against BzATP-induced cytotoxicity[2]. In Vivo: A chroni treatment with A-804598 (intraperitoneal injection; 30 mg/kg; five times a week) decreases the expression of LC3B-II and SQSTM1/p62 in lumbar spinal cord at end stage of disease[3].

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