SKU : MC507290
CAS Number : 1129669-05-1
Molecular Formula : C22H20FN3O2 | Molecular Weight : 377.41
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
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Chemical Name | IM-12 |
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CAS Number | 1129669-05-1 |
MDL Number | MFCD20527313 |
Molecular Formula | C22H20FN3O2 |
Molecular Weight | 377.41 |
IM-12 is an inhibitor of GSK-3β, with an IC50 of 53 nM, and also enhances Wnt signalling. IC50 & Target: IC50: 53 nM (GSK-3β)[1] In Vitro: IM-12 inhibits GSK-3β in ReNcell VM cells, with I50 of 3.8 μM. IM-12 (3 μM) enhances the β-catenin amount, with no further effect at lower or higher concentration. IM-12 (3 μM) also attenuates the proliferation of ReNCell VM cells. IM-12 increases TCF-activity of ReNcell VM[1].
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