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113158-34-2 | Norbinaltorphimine dihydrochloride

Norbinaltorphimine dihydrochloride NLT 98%

SKU : MC507365

CAS Number : 113158-34-2

Molecular Formula : C40H45Cl2N3O6 | Molecular Weight : 734.71

Synonyms : nor-Binaltorphimine dihydrochloride;nor-BNI dihydrochloride

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Purity NLT 98%
Storage at 20ºC 2 years

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Chemical Name Norbinaltorphimine dihydrochloride
CAS Number 113158-34-2
MDL Number MFCD00069374
Molecular Formula C40H45Cl2N3O6
Molecular Weight 734.71
Synonyms nor-Binaltorphimine dihydrochloride;nor-BNI dihydrochloride
Introduction of 113158-34-2 :

Norbinaltorphimine dihydrochloride is a potent and selective κ opioid receptor antagonist. IC50 & Target: κ opioid receptor[1] In Vitro: Norbinaltorphimine reversibly antagonize the effects of κ agonists with pA2 values of 10.2-10.4. Norbinaltorphimine is much less potent as an antagonist at μ and δ receptors, pA2 values are 7.4-7.6 and 7.6-7.8, respectively[1]. In Vivo: Norbinaltorphimine has weak and inconsistent effects on THC-induced taste avoidance in adolescent rats in that Norbinaltorphimine both attenuates and strengthens taste avoidance dependent on dose and trial. Norbinaltorphimine has limited impact on the final one-bottle avoidance and no effects on the two-bottle preference test. Interestingly, Norbinaltorphimine has no effect on THC-induced taste avoidance in adult rats as well[2]. Norbinaltorphimine pretreatment significantly attenuates stress-induced reinstatement of nicotine-CPP, but has no effect on nicotine-primed reinstatement[3].

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