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1135695-98-5 | Q-VD-OPh

Q-VD-OPh NLT 98%

SKU : MC507519

CAS Number : 1135695-98-5

Molecular Formula : C26H27F2N3O7 | Molecular Weight : 531.51

Synonyms : QVD-OPH;Quinoline-Val-Asp-Difluorophenoxymethylketone

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Purity NLT 98%
Storage at 20ºC 2 years

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Chemical Name Q-VD-OPh
CAS Number 1135695-98-5
MDL Number MFCD20527311
Molecular Formula C26H27F2N3O7
Molecular Weight 531.51
Synonyms QVD-OPH;Quinoline-Val-Asp-Difluorophenoxymethylketone
Introduction of 1135695-98-5 :

Q-VD-OPh is an irreversible pan-caspase inhibitor with potent antiapoptotic properties; inhibits caspase 7 with an IC50 of 48 nM and 25-400 nM for other caspases including caspase 1, 3, 8, 9, 10, and 12. Q-VD-OPh can inhibits HIV infection. Q-VD-OPh is able to cross the blood-brain barrier. IC50 & Target: IC50: 48 nM (caspase 7), 25-400 nM (caspase 1, 3, 8, 9, 10, and 12)[1] In Vitro: Q-VD-OPh is a potent inhibitor of caspase-7 with an IC50 of 48 nM utilizing a cell-free assay consisting of human recombinant caspase-7, Q-VD-OPh, and the substrate AMC-DEVD-pNa[1]. Q-VD-OPh fully inhibits caspase-3 and -7 activity at 0.05 μM. Caspase-8 is also inhibited at low Q-VD-OPh concentrations. The cleavage of PARP-1 is fully prevented at 10 μM Q-VD-OPh. DNA fragmentation and disruption of the cell membrane functionality are both prevented at 2 μM Q-VD-OPh[2]. Q-VD-OPh is significantly more effective in preventing apoptosis than the widely used inhibitors, ZVAD-fmk and Boc-D-fmk, and is also equally effective in preventing apoptosis mediated by the three major apoptotic pathways, caspase 9/3, caspase 8/10, and caspase12. Q-VD-OPh is not toxic to cells even at extremely high concentrations[3]. QVD is also able to increase the expression of differentiation markers in acute myeloid leukemia (AmL) blasts. QVD alone or combined with VDDs increases differentiation and HPK1-cJun signaling in AmL cell context-dependent manner[4]. In Vivo: Chronic treatment with Q-VD-OPh prevents caspase-7 activation and limits the pathological changes associated with tau, including caspase cleavage. Q-VD-OPh could be a potential therapeutic compound for the treatment of Alzheimer's disease[1].

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