SKU : MC530219
CAS Number : 165800-06-6
Molecular Formula : C5H12N2O8P2 | Molecular Weight : 290.10
Synonyms : Zoledronate monohydrate;CGP 42446 monohydrate;CGP42446A monohydrate;ZOL 446 monohydrate
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
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Chemical Name | Zoledronic acid (monohydrate) |
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CAS Number | 165800-06-6 |
MDL Number | MFCD08448695 |
Molecular Formula | C5H12N2O8P2 |
Molecular Weight | 290.10 |
Synonyms | Zoledronate monohydrate;CGP 42446 monohydrate;CGP42446A monohydrate;ZOL 446 monohydrate |
Zoledronic acid monohydrate is a third-generation, nitrogen-containing bisphosphonate, inhibits osteoclast-mediated bone resorption, and also has antitumor activity. In Vitro: Zoledronic acid monohydrate induces apoptosis in HGF and HaCaT cells at 0.5 μM, and causes cell death at 1-5 μM[1]. Zoledronic Acid (50, 100 μM) causes dose- and time-dependent apoptosis in CNE-2Z cells after treatment for 24, 48, and 72 h. Zoledronic Acid (50 μM) also increases the level of ROS, which is supposed to mediate Cl- currents activation in CNE-2Z cells. Furthermore, the apoptosis and chloride currents induced by Zoledronic Acid can be blocked by knocking down ClC-3 protein expression[2].
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