SKU : MC537035
CAS Number : 197250-15-0
Molecular Formula : C70H107N19O19S | Molecular Weight : 1550.78
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
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Chemical Name | Gap 26 |
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CAS Number | 197250-15-0 |
MDL Number | MFCD06411601 |
Molecular Formula | C70H107N19O19S |
Molecular Weight | 1550.78 |
Gap 26 is a connexin mimetic peptide corresponding to the residues 63-75 of connexin 43, which is a gap junction blocker. IC50 & Target: Gap Junction Protein[1] In Vitro: Gap 26 is corresponding to the residues 63-75 of connexin 43, which is a gap junction blocker. Gap 26 (100-300 μM) dose-dependently reduces the rhythmic responses of rabbit superior mesenteric arteries, with IC50 of 28.4 ± 3.4 μM[1]. Gap 26 abolishes the inositol-1,4,5-trisphosphate (InsP3)-triggered ATP response and reduces the ATP release, but has no effect on gap junctional coupling[2].
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