SKU : MC537198
CAS Number : 198470-84-7
Molecular Formula : C19H18N2O4S | Molecular Weight : 370.42
Synonyms : SC 69124
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
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Chemical Name | Parecoxib |
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CAS Number | 198470-84-7 |
MDL Number | MFCD08141856 |
Molecular Formula | C19H18N2O4S |
Molecular Weight | 370.42 |
Synonyms | SC 69124 |
Parecoxib is a potent and selective COX-2 inhibitor. IC50 value: Target: COX-2 in vitro: The prodrug Parecoxib as well as its active metabolite val have a specific affinity to the cannabinoid (CB) receptor measured in CB1-expressing HEK 293 cells and rat brain tissue [1]. in vivo: Adult male Sprague-Dawley rats were administered parecoxib (10 or 30 mg kg(-1), IP) or isotonic saline twice a day starting 24 h after middle cerebral artery occlusion (MCAO) for three consecutive days [2]. The selective COX-2 inhibitor parecoxib was delivered 20 min before or 20 min after the incision by intraperitoneal injection. Pretreatment with parecoxib markedly attenuated the pain hypersensitivity induced by incision [3].
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