SKU : MC537199
CAS Number : 198470-85-8
Molecular Formula : C19H17N2NaO4S | Molecular Weight : 392.40
Synonyms : SC 69124A
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
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Chemical Name | Parecoxib (Sodium) |
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CAS Number | 198470-85-8 |
MDL Number | MFCD04972608 |
Molecular Formula | C19H17N2NaO4S |
Molecular Weight | 392.40 |
Synonyms | SC 69124A |
Parecoxib Sodium (SC 69124A) is a potent and selective COX-2 inhibitor. IC50 value: Target: COX-2 in vitro: The prodrug Parecoxib as well as its active metabolite val have a specific affinity to the cannabinoid (CB) receptor measured in CB1-expressing HEK 293 cells and rat brain tissue [1]. in vivo: Adult male Sprague-Dawley rats were administered parecoxib (10 or 30 mg kg(-1), IP) or isotonic saline twice a day starting 24 h after middle cerebral artery occlusion (MCAO) for three consecutive days [2]. The selective COX-2 inhibitor parecoxib was delivered 20 min before or 20 min after the incision by intraperitoneal injection. Pretreatment with parecoxib markedly attenuated the pain hypersensitivity induced by incision [3].
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