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198470-85-8 | Parecoxib (Sodium)

Parecoxib (Sodium) NLT 98%

SKU : MC537199

CAS Number : 198470-85-8

Molecular Formula : C19H17N2NaO4S | Molecular Weight : 392.40

Synonyms : SC 69124A

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Purity NLT 98%
Storage at 20ºC 2 years

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Chemical Name Parecoxib (Sodium)
CAS Number 198470-85-8
MDL Number MFCD04972608
Molecular Formula C19H17N2NaO4S
Molecular Weight 392.40
Synonyms SC 69124A
Introduction of 198470-85-8 :

Parecoxib Sodium (SC 69124A) is a potent and selective COX-2 inhibitor. IC50 value: Target: COX-2 in vitro: The prodrug Parecoxib as well as its active metabolite val have a specific affinity to the cannabinoid (CB) receptor measured in CB1-expressing HEK 293 cells and rat brain tissue [1]. in vivo: Adult male Sprague-Dawley rats were administered parecoxib (10 or 30 mg kg(-1), IP) or isotonic saline twice a day starting 24 h after middle cerebral artery occlusion (MCAO) for three consecutive days [2]. The selective COX-2 inhibitor parecoxib was delivered 20 min before or 20 min after the incision by intraperitoneal injection. Pretreatment with parecoxib markedly attenuated the pain hypersensitivity induced by incision [3].

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