SKU : MC537246
CAS Number : 19879-30-2
Molecular Formula : C21H22O4 | Molecular Weight : 338.40
Synonyms : 7-O-Methylbavachin;Bavachinin A
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
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Chemical Name | Bavachinin |
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CAS Number | 19879-30-2 |
MDL Number | MFCD06858396 |
Molecular Formula | C21H22O4 |
Molecular Weight | 338.40 |
Synonyms | 7-O-Methylbavachin;Bavachinin A |
Bavachinin(7-O-Methylbavachin) is a natural compound isolated from the Chinese herb Fructus Psoraleae;has potent anti-angiogenic activity. IC50 value: Target: in vitro: Isobavachalcone significantly inhibits both oligomerization and fibrillization of Aβ42, whereas bavachinin inhibits fibrillization and leads to off-pathway aggregation. Both of the compounds attenuated Aβ42-induced toxicity in a SH-SY5Y cell model [1]. Bavachinin, has potent anti-angiogenic activity in vitro and in vivo. Bavachinin inhibited increases in HIF-1α activity in human KB carcinoma (HeLa cell derivative) and human HOS osteosarcoma cells under hypoxia in a concentration-dependent manner, probably by enhancing the interaction between von Hippel-Lindau (VHL) and HIF-1α [2]. in vivo: significantly inhibited Th2 cytokine production, including IL-4, IL-5 and IL-13. Notably, this compound almost completely blocked inflammation in the ovalbumin (OVA)-sensitized animal asthma model [3].
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