Fmoc-Glu(2-phenylisopropyl ester)-OH 98% Min.
CAS Number : 200616-39-3
Molecular Formula : C29H29NO6 | Molecular Weight : 487.54 | MDL Number : MFCD00672323
Synonyms : Fmoc-Glu(OPp)-OH;Fmoc-Glu(O-2-PhiPr)-OH
Glu-derivative for the selective modification of the γ-carboxyl group. The OPp group can be removed selectively in the presence of Boc/OtBu with 1% TFA/DCM. Ocampo et al. applied OPp protection during the synthesis of a peptide-oligonucleotide conjugate and cleaved it with 3% trichloroacetic acid in DCM. Tofteng et al. generated a backbone pyroglutamyl imide moiety from C-terminal Glu after selective on-resin OPp removal.
SKU : MC437305