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218457-67-1 | CB-103

CB-103 NLT 98%

SKU : MC541267

CAS Number : 218457-67-1

Molecular Formula : C15H18N2O | Molecular Weight : 242.32

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Purity NLT 98%
Storage at 20ºC 2 years

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Chemical Name CB-103
CAS Number 218457-67-1
MDL Number MFCD00052647
Molecular Formula C15H18N2O
Molecular Weight 242.32
Introduction of 218457-67-1 :

CB-103 is a first-in-class orally active notch signaling pathway inhibitor extracted from patent US9296682B2. CB-103 has anti-tumor activity[1][2][3]. IC50 & Target: notch signaling pathway[1] In Vitro: CB-103 acts as a Pan-NOTCH inhibitor by targeting NOTCH transcriptional activation complex[2].
CB-103 has shown the ability to block NOTCH signaling in human T cell acute lymphoblastic leukemia cancer cell lines[2].
CB-103 exhibits anti-tumor efficacy in GSI resistant T-ALL cell lines[2].
In Vivo: CB-103 inhibits NOTCH dependent cellular processes in mice[2].
CB-103 blocks in vivo growth of PDX models of T-ALL[2].
CB-103 (25 mg/kg; i.p./p.o.; 2x daily; for 2 weeks) inhibits growth of GSI/Mab resistant triple negative breast cancer[3].
CB-103 exhibits anti-tumor activity in xenograft models of human T-ALL and mouse mammary tumors[3].

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