SKU : MC543695
CAS Number : 24211-30-1
Molecular Formula : C17H16O5 | Molecular Weight : 300.31
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
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Chemical Name | Farrerol |
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CAS Number | 24211-30-1 |
MDL Number | MFCD00017315 |
Molecular Formula | C17H16O5 |
Molecular Weight | 300.31 |
Farrerol is a bioactive constituent of Rhododendron, with broad activities such as anti-oxidative, anti-inflammatory, anti-tumor, neuroprotective and hepatoprotective effects[1][2][3][4][5][6]. In Vitro: Farrerol observably reduces the production of inflammatory mediators including IL-1β, IL-6, TNF-α, COX-2, and iNOS in LPS-induced RAW264.7 cells via suppressing AKT, ERK1/2, JNK1/2, and NF-κB p65 phosphorylation[1].
Farrerol attenuates β-amyloid-induced oxidative stress and inflammation through Nrf2/Keap1 pathway in a microglia cell line[2].
Farrerol inhibits angiogenesis through Akt/mTOR, Erk and Jak2/Stat3 signal pathway[3].
Farrerol overcomes the invasiveness of lung squamous cell carcinoma cells by regulating the expression of inducers of epithelial mesenchymal transition[4].
Farrerol ameliorates acetaminophen-induced hepatotoxicity via activation of Nrf2 and autophagy[6].
In Vivo: Farrerol protects dopaminergic neurons in a rat model of lipopolysaccharide-induced Parkinson's disease by suppressing the activation of the AKT and NF-κB signaling pathways[5].
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