SKU : MC544611
CAS Number : 25451-15-4
Molecular Formula : C11H14N2O4 | Molecular Weight : 238.24
Synonyms : W-554;ADD-03055
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
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Chemical Name | Felbamate |
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CAS Number | 25451-15-4 |
MDL Number | MFCD00865296 |
Molecular Formula | C11H14N2O4 |
Molecular Weight | 238.24 |
Synonyms | W-554;ADD-03055 |
Felbamate (W-554) is a potent nonsedative anticonvulsant whose clinical effect may be related to the inhibition of N-methyl-D-aspartate (NMDA). IC50 & Target: NMDA Receptor[1]. In Vitro: Felbamate (W-554) is an anti-epileptic drug used in the treatment of epilepsy. It is used to treat partial seizures (with and without generalization) in adults and partial and generalized seizures associated with Lennox-Gastaut syndrome in children. However, an increased risk of potentially fatal aplastic anemia and/or liver failure limit the drugs usage to severe refractory epilepsy[1]. Felbamate (W-554) has been proposed to a unique dual mechanism of action as a positive modulator of GABAA receptors and as a blocker of NMDA receptors, particularly isoforms containing the NR2B subunit. Although it is clear that felbamate does cause pharmacological inhibition of NMDA receptor of relevance of NMDA receptor blockade as a strategy for the treatment of human epilepsy has been questioned. Therefore, the importance of the effects of felbamate on NMDA receptors to its therapeutic action in epilepsy is uncertain[2].
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