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288628-05-7 | Irosustat

Irosustat NLT 98%

SKU : MC546562

CAS Number : 288628-05-7

Molecular Formula : C14H15NO5S | Molecular Weight : 309.34

Synonyms : STX64;BN83495;667-Coumate

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Purity NLT 98%
Storage at 20ºC 2 years

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Chemical Name Irosustat
CAS Number 288628-05-7
MDL Number MFCD12912443
Molecular Formula C14H15NO5S
Molecular Weight 309.34
Synonyms STX64;BN83495;667-Coumate
Introduction of 288628-05-7 :

Irosustat is a potent steroid sulfatase inhibitor, with an IC50 of 8 nM, and exhibits anti-breast cancer activity. IC50 & Target: IC50: 8 nM (Steroid sulfatase)[1], 0.2 nM (Steroid sulfatase, MCF-7 cells)[2] In Vitro: Irosustat (667 COUMATE) is a potent steroid sulfatase inhibitor, with an IC50 of 8 nM[1]. Irosustat (667 COUMATE) inhibits steroid sulphatase (STS) activity in MCF-7 cells with an IC50 of 0.2 nM, but has no effect on the morphology or proliferation of MCF-7 cells at 10 μM[2]. In Vivo: Irosustat potently inhibits rat liver, with inhibition of >90% when at a 1 mg/kg concentration. Irosustat (2 mg/kg, p.o. for 5 d) blocks the uterine growth stimulated by oestrone sulfate (E1S) in ovariectomized rats. In addition, Irosustat (2, 10 mg/kg, p.o.) plus E1S dose-dependently decreases the growth of NMU-induced mammary tumors in ovariectomized rats[1]. Irosustat (667 COUMATE; 10 mg/kg, p.o.) shows 97.9 ± 0.06% inhibition on steroid sulphatase (STS) activity in rat liver[2].

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