SKU : MC547979
CAS Number : 313380-27-7
Molecular Formula : C19H11F4N3OS2 | Molecular Weight : 437.43
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
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Chemical Name | FDI-6 |
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CAS Number | 313380-27-7 |
MDL Number | MFCD01416826 |
Molecular Formula | C19H11F4N3OS2 |
Molecular Weight | 437.43 |
FDI-6 is an inhibitor of FOXM1. FDI-6 binds directly to FOXM1 protein, to displace FOXM1 from genomic targets in MCF-7 breast cancer cells, and induce concomitant transcriptional down-regulation. IC50 & Target: FOXM1[1] In Vitro: FDI-6 is characterized in depth and is shown to bind directly to FOXM1 protein, to displace FOXM1 from genomic targets in MCF-7 breast cancer cells, and induce concomitant transcriptional down-regulation. MDA-MB-231 ER-negative breast and PEO-1 ovarian cancer cells are sensitive to FDI-6 in cell viability assays (GI50=21.8 μM and 18.1 μM, respectively) and exhibit comparable down-regulation of CDC25B after a 3 h treatment with FDI-6. The transcription factor FOXM1 regulates a network of proliferation-associated genes critical to mitotic spindle assembly, chromosome segregation, and G2/M transition, with depletion leading to cell cycle arrest. Importantly, aberrant up-regulation of FOXM1 has been shown to be a key driver of cancer progression and has been proposed as an initiating factor of oncogenesis[1].
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