SKU : MC552116
CAS Number : 37988-18-4
Molecular Formula : C15H21N3O6 | Molecular Weight : 339.34
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
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Chemical Name | LM22A-4 |
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CAS Number | 37988-18-4 |
MDL Number | MFCD00382831 |
Molecular Formula | C15H21N3O6 |
Molecular Weight | 339.34 |
LM22A-4 is a specific agonist of tyrosine kinase receptor B, used for neurological disease research. In Vitro: LM22A-4 significantly up-regulates OPN and ALPase mRNA expression in a dose-dependent manner and OC mRNA level is significantly increased by 5 μM of LM22A-4. LM22A-4 significantly increases OPN, ALPase and OC mRNA expression in a time-dependent manner. LM22A-4 stimulated OPN and OC mRNA expression in HCEM cells cultured with mineralizing media[2]. In Vivo: LM22A-4 (10 mg/kg, i.p.) significantly reduces the degree of tissue injury and apoptosis (TUNEL staining and caspase-3 and Bcl-2 expression) compared with vehicle treated group. LM22A-4 also significantly ameliorates the recovery of limb function. LM22A-4 (10 mg/kg) treatment results in a significant increase in neuron number. LM22A-4 administration (10 mg/kg) significantly improves the neurological scores compared with those of the solvent-treated animals[1].
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