SKU : MC552650
CAS Number : 39025-23-5
Molecular Formula : C21H28O2 | Molecular Weight : 312.45
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
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Chemical Name | (Z)-Guggulsterone |
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CAS Number | 39025-23-5 |
MDL Number | MFCD01310757 |
Molecular Formula | C21H28O2 |
Molecular Weight | 312.45 |
Z-guggulsterone, a constituent of Indian Ayurvedic medicinal plant Commiphora mukul, inhibits the growth of human prostate cancer cells by causing apoptosis. Z-guggulsterone inhibits angiogenesis by suppressing the VEGF–VEGF-R2–Akt signaling axis[1]. IC50 & Target: VEGF-VEGF-R2-Akt[1] In Vitro: Z-guggulsterone (10, 20 μM; 24 or 48 hours) causes a decrease in the level of VEGF-R2 protein in HUVEC[1]. In Vivo: Z-guggulsterone (oral; 1 mg; 5 times/week) results in a statistically significantly decrease in tumor volume and wet tumor weight[1].
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