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76963-41-2 | Nizatidine

Nizatidine NLT 98%

SKU : MC571103

CAS Number : 76963-41-2

Molecular Formula : C12H21N5O2S2 | Molecular Weight : 331.46

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Purity NLT 98%
Storage at 20ºC 2 years

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Chemical Name Nizatidine
CAS Number 76963-41-2
MDL Number MFCD00865660
Molecular Formula C12H21N5O2S2
Molecular Weight 331.46
Introduction of 76963-41-2 :

Nizatidine is a histamine H2 receptor antagonist with low toxicity that inhibits gastric acid secretion. Target: Histamine H2 Receptor Nizatidine, a selective histamine H2-receptor antagonist, is a potent inhibitor of gastric acid secretion, with IC50 of 0.9 nM. Nizatidine exhibits maximal inhibition of gastric acid in rats within the first hour of drug administration, with EC50 of 1.383 μmol/kg [1]. Nizatidine also reversibly inhibits acetylcholinesterase (AChE), with IC50 of 6.7 μM, and the inhibition is noncompetitive, with a Ki value of 7.4 μM. Nizatidine (0.3-3 mg/kg, i.v.) significantly increases the motor index of gastrointestinal (GI) motility in a dose-dependent manner. Nizatidine inhibits gastric acid secretion with ED50 and ED90 of 0.18 and 3.22 mg/kg in dogs, and 2.94 and 19.6 mg/kg in rats, respectively [2].

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