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Fmoc-Cys(SASRIN™ resin)-OH (200-400 mesh)

Fmoc-Cys(SASRIN™ resin)-OH (200-400 mesh) 98% Min.

SKU : MC437209

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Purity 98% Min.
Storage +5 ± 3 ºC

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Chemical Name Fmoc-Cys(SASRIN™ resin)-OH (200-400 mesh)
This resin has been developed to allow C-terminal modification of cysteine-containing peptides. Fmoc-protected cysteine is linked to SASRIN™-resin by its thiol moiety, which thus is already protected. After derivatization of the carboxylic acid (and, if desired, standard Fmoc-SPPS) lthe modified cysteine derivative can be cleaved with TFA/water/triisopropylsilane (94:4:2, v/v/v) from the SASRIN™-resin. Extending the peptide chain at the C-terminus can be achieved by activation of the side-chain linked cysteine carboxylic acid and coupling to additional amino acids.
Cys linked to a resin by its thiol function was oxidized with MCPBA after esterification and Nα-modification (Yamada et al.). DBU-induced elimination yielded dehydroalanine derivatives.

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