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1000578-26-6 | AS19

AS19 NLT 98%

SKU : MC500207

CAS Number : 1000578-26-6

Molecular Formula : C18H25N3 | Molecular Weight : 283.41

Synonyms : (2S)-(+)-5-(1,3,5-Trimethylpyrazol-4-YL)-2-(dimethylamino)tetralin

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Purity NLT 98%
Storage at 20ºC 2 years
*The above information is for reference only.
Chemical Name AS19
CAS Number 1000578-26-6
Molecular Formula C18H25N3
Molecular Weight 283.41
Synonyms (2S)-(+)-5-(1,3,5-Trimethylpyrazol-4-YL)-2-(dimethylamino)tetralin
Introduction of 1000578-26-6 :

AS19 is a potent, selective 5-HT7 receptor agonist with an IC50 value of 0.83 nM and a Ki of 0.6 nM. AS19 is selective for 5-HT7 over 5-HT1A, 5-HT1B, 5-HT1D, and 5-HT5A receptors (Kis = 89.7 nM, 490 nM, 6.6 nM and 98.5 nM, respectively). AS19 enhances memory consolidation and reverses Scopolamine- or Dizocilpine-induced amnesia[1][2][3]. In Vitro: The proliferation of T-cell from parachlorophenylalanine-treated mice is significantly reduced, addition of AS19 (1 μM) completely restores T-cell proliferation after 48 hours[2]. In Vivo: AS19 (0.5-10 mg/kg; subcutaneous injection; for 24 hours; male Wistar rats) treatment improves memory consolidation in an autoshaping Pavlovian/instrumental learning task[1].

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