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1001382-14-4 | Ipatasertib-NH2

Ipatasertib-NH2 NLT 98%

SKU : MC500354

CAS Number : 1001382-14-4

Molecular Formula : C21H26ClN5O2 | Molecular Weight : 415.92

Synonyms : GDC-0068-NH2;RG7440-NH2

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Purity NLT 98%
Storage at 20ºC 2 years
*The above information is for reference only.
Chemical Name Ipatasertib-NH2
CAS Number 1001382-14-4
Molecular Formula C21H26ClN5O2
Molecular Weight 415.92
Synonyms GDC-0068-NH2;RG7440-NH2
Introduction of 1001382-14-4 :

Ipatasertib-NH2 (GDC-0068-NH2;RG7440-NH2) is a ligand for target protein AKT for PROTAC, binds to lenalidomide, a ligand of ubiquitin E3 ligase cereblon (CRBN), via a ten-hydrocarbon linker to form INY-03-041 (HY-133120) to degrade AKT[1]. IC50 & Target: AKT[1] In Vitro: PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

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