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1001404-83-6 | AAI101

AAI101 NLT 98%

SKU : MC500363

CAS Number : 1001404-83-6

Molecular Formula : C11H14N4O5S | Molecular Weight : 314.32

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Purity NLT 98%
Storage at 20ºC 2 years
*The above information is for reference only.
Chemical Name AAI101
CAS Number 1001404-83-6
Molecular Formula C11H14N4O5S
Molecular Weight 314.32
Introduction of 1001404-83-6 :

AAI101 is an extended-spectrum β-lactamase inhibitor, against many resistant Gram-negative pathogens. In Vitro: AAI101 shows potent activity against specific resistance phenotypes with MIC50 and MIC90 of 0.125 mg/L and 64 mg/L[1]. Cefepime-AAI101 MICs decreases with increasing concentrations of AAI101 (over the range from 1 to 16 mg/L) for most strains, demonstrating a concentration dependence of AAI101 on restoration of the antibacterial activity of the cephalosporin[1]. In Vivo: In neutropenic animals, cefepime-AAI101 treatment results in reductions in bacterial density of ≥0.5 log10 CFU for 12 of the 20 strains tested and reductions of ≥1 log10 CFU for 6 of these. Increases in bacterial density are for only four strains, three of which have cefepime-AAI101 MICs of ≥64 mg/L, irrespective of the AAI101 concentration[2].

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