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1001409-50-2 | MP7

MP7 NLT 98%

SKU : MC500364

CAS Number : 1001409-50-2

Molecular Formula : C28H22F2N4O4 | Molecular Weight : 516.50

Synonyms : PDK1 inhibitor

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Purity NLT 98%
Storage at 20ºC 2 years
*The above information is for reference only.
Chemical Name MP7
CAS Number 1001409-50-2
MDL Number MFCD18642668
Molecular Formula C28H22F2N4O4
Molecular Weight 516.50
Synonyms PDK1 inhibitor
Introduction of 1001409-50-2 :

MP7 (PDK1 inhibitor) is a phosphoinositide-dependent kinase-1 (PDK1) inhibitor. IC50 & Target: PDK1[1] In Vitro: Cell counting of U87MG-derived glioma stem cells (GSCs) confirms that Alisertib and, to a minor extent, MP7 (PDK1 inhibitor) are able to decrease the number of viable cells. When combined together, GSC viability is further reduced with respect to single-treated cells. As observed in U87MG cells, when used at the highest concentrations (i.e., 1.5 μM Alisertib and 2.5 μM MP7), a significant enhancement in the number of dead cells is evidenced. Following 72 h treatment, MP7 alone does not show a significant inhibition of glioblastoma multiforme (GBM) proliferation. MP7 has been shown to have only minimal effects on monolayer cell growth in several cancer cell lines, with IC50 values in the micromolar range[1].

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