Product Number : MC500364
CAS Number : 1001409-50-2
Molecular Formula : C28H22F2N4O4 | Molecular Weight : 516.50
Synonyms : PDK1 inhibitor
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
MolCore specializes in manufacturing high-purity CAS No.1001409-50-2, MP7 with the molecular formula C28H22F2N4O4 and molecular weight 516.50 delivering critical API intermediates for global pharmaceutical and research industries, certified under ISO quality systems. |
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Chemical Name | MP7 |
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CAS Number | 1001409-50-2 |
MDL Number | MFCD18642668 |
Molecular Formula | C28H22F2N4O4 |
Molecular Weight | 516.50 |
Synonyms | PDK1 inhibitor |
MP7 (PDK1 inhibitor) is a phosphoinositide-dependent kinase-1 (PDK1) inhibitor. IC50 & Target: PDK1[1] In Vitro: Cell counting of U87MG-derived glioma stem cells (GSCs) confirms that Alisertib and, to a minor extent, MP7 (PDK1 inhibitor) are able to decrease the number of viable cells. When combined together, GSC viability is further reduced with respect to single-treated cells. As observed in U87MG cells, when used at the highest concentrations (i.e., 1.5 μM Alisertib and 2.5 μM MP7), a significant enhancement in the number of dead cells is evidenced. Following 72 h treatment, MP7 alone does not show a significant inhibition of glioblastoma multiforme (GBM) proliferation. MP7 has been shown to have only minimal effects on monolayer cell growth in several cancer cell lines, with IC50 values in the micromolar range[1].
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