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1001908-89-9 | SRT 2183

SRT 2183 NLT 98%

SKU : MC500429

CAS Number : 1001908-89-9

Molecular Formula : C27H24N4O2S | Molecular Weight : 468.57

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Purity NLT 98%
Storage at 20ºC 2 years
*The above information is for reference only.
Chemical Name SRT 2183
CAS Number 1001908-89-9
Molecular Formula C27H24N4O2S
Molecular Weight 468.57
Introduction of 1001908-89-9 :

SRT 2183 is a selective Sirtuin-1 (SIRT1) activator with an EC1.5 value of 0.36 μM[1]. SRT 2183 induces growth arrest and apoptosis, concomitant with deacetylation of STAT3 and NF-κB, and reduction of c-Myc protein levels[2]. IC50 & Target: EC1.5: 0.36 μM (SIRT1)[1] In Vitro: SRT 2183 (1-10 μM; 24-72 hours) inhibits the growth of Reh and Nalm-6 cells in a time- and dose-dependent manner[2].
SRT 2183 (5-10 μM in Reh cells; 10 μM in Ly3 cells; 24 hours) induces expression of DNA-damage response genes associated with accumulation of phospho-H2A.X levels[2].
SRT2183 inhibits RANKL-induced osteoclast differentiation, fusion and resorptive capacity without affecting osteoclast survival[3].

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