Setogepram NLT 98%
SKU : MC500455
CAS Number : 1002101-19-0
Molecular Formula : C13H18O2 | Molecular Weight : 206.28
Synonyms : PBI-4050
Quote Request| Purity | NLT 98% |
|---|---|
| Storage | at 20ºC 2 years |
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| Chemical Name | Setogepram |
|---|---|
| CAS Number | 1002101-19-0 |
| Molecular Formula | C13H18O2 |
| Molecular Weight | 206.28 |
| Synonyms | PBI-4050 |
Setogepram (PBI-4050) acts as an orally active agonist for GPR40 and as an antagonist or inverse agonist for GPR84[1]. Setogepram (PBI-4050) decreases renal, liver and pancreatic fibrosis[1][2]. Setogepram (PBI-4050) exerts anti-fibrotic, anti-inflammatory and anti-proliferative actions[2]. IC50 & Target: GPR40, GPR84[1] In Vitro: Setogepram (PBI-4050; 500 µM; 24 hours) inhibits TGF-β (10 ng/mL)-activated human hepatic stellate cells (HSCs) proliferation[2].
Setogepram (PBI-4050; 250 or 500 µM; 24hours) dose-dependently arrests HSCs at the G0/G1 phase without inducing apoptosis[2]. In Vivo: Setogepram (PBI-4050; 100 mg/kg/day; gavage from 8-20 weeks of age) markedly decreases hyperglycemia and markedly improvea glucose tolerance in type 2 diabetes eNOS-/-db/db mice[1].
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