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1002101-19-0 | Setogepram

Setogepram NLT 98%

SKU : MC500455

CAS Number : 1002101-19-0

Molecular Formula : C13H18O2 | Molecular Weight : 206.28

Synonyms : PBI-4050

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Purity NLT 98%
Storage at 20ºC 2 years
*The above information is for reference only.
Chemical Name Setogepram
CAS Number 1002101-19-0
Molecular Formula C13H18O2
Molecular Weight 206.28
Synonyms PBI-4050
Introduction of 1002101-19-0 :

Setogepram (PBI-4050) acts as an orally active agonist for GPR40 and as an antagonist or inverse agonist for GPR84[1]. Setogepram (PBI-4050) decreases renal, liver and pancreatic fibrosis[1][2]. Setogepram (PBI-4050) exerts anti-fibrotic, anti-inflammatory and anti-proliferative actions[2]. IC50 & Target: GPR40, GPR84[1] In Vitro: Setogepram (PBI-4050; 500 µM; 24 hours) inhibits TGF-β (10 ng/mL)-activated human hepatic stellate cells (HSCs) proliferation[2].
Setogepram (PBI-4050; 250 or 500 µM; 24hours) dose-dependently arrests HSCs at the G0/G1 phase without inducing apoptosis[2]. In Vivo: Setogepram (PBI-4050; 100 mg/kg/day; gavage from 8-20 weeks of age) markedly decreases hyperglycemia and markedly improvea glucose tolerance in type 2 diabetes eNOS-/-db/db mice[1].

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