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1002789-86-7 | TZ9

TZ9 NLT 98%

SKU : MC500517

CAS Number : 1002789-86-7

Molecular Formula : C17H14N6O4 | Molecular Weight : 366.33

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Purity NLT 98%
Storage at 20ºC 2 years
*The above information is for reference only.
Chemical Name TZ9
CAS Number 1002789-86-7
Molecular Formula C17H14N6O4
Molecular Weight 366.33
Introduction of 1002789-86-7 :

TZ9 is a novel inhibitor of Rad6 ubiquitin conjugating enzyme(E2 enzyme); inhibits MDA-MB-231 cell proliferation with IC50 of ~6 uM. IC50 value: 6 uM [1] Target: Rad6 inhibitor The bulk of MDA-MB-231 cells treated with 10 μmol/L or more SMI #9 displayed a round morphology compared with controls and less than 5 μmol/L doses of SMI #9. Simultaneous comparison of SMIs #8 and 9 confirmed SMI #9 inhibits Matrigel-induced migration of MDA-MB-231 cells in a dose-dependent manner compared with SMI #8. 5 μmol/L SMI #9 treatment triggered morphologic changes consistent with apoptosis in a time-dependent manner. 5 μmol/L SMI #9 treatment of MDA-MB-231 cells for 24 hours increased the proportion of G2–M-arrested cells by 2-fold and was accompanied by a proportional decrease in S-phase cells. SMIs #8 or 9 treatments dramatically reduced β-catenin staining as visualized by reduced merged Rad6/β-catenin yellow fluorescence.

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