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100286-90-6 | Irinotecan (hydrochloride)

Irinotecan (hydrochloride) NLT 98%

SKU : MC500520

CAS Number : 100286-90-6

Molecular Formula : C33H38N4O6 | Molecular Weight : 586.68

Synonyms : CPT-11 hydrochloride;Camptothecin 11 hydrochloride

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Purity NLT 98%
Storage at 20ºC 2 years
*The above information is for reference only.
Chemical Name Irinotecan (hydrochloride)
CAS Number 100286-90-6
MDL Number MFCD00866307
Molecular Formula C33H38N4O6
Molecular Weight 586.68
Synonyms CPT-11 hydrochloride;Camptothecin 11 hydrochloride
Introduction of 100286-90-6 :

Irinotecan hydrochloride is a topoisomerase I inhibitor mainly used to treat colon cancer and rectal cancer. IC50 & Target: Topoisomerase I[1] In Vitro: Irinotecan hydrochloride is a topoisomerase I inhibitor. Irinotecan inhibits the growth of LoVo and HT-29 cells, with IC50s of 15.8 ± 5.1 and 5.17 ± 1.4 μM, respectively, and induces similar amounts of cleavable complexes in both in LoVo and HT-29 cells[2]. Irinotecan suppresses the proliferation of human umbilical vein endothelial cells (HUVEC), with an IC50 of 1.3 μM[3]. In Vivo: Irinotecan (CPT-11, 5 mg/kg) significantly inhibits the growth of tumors by intratumoral injection daily for 5 days, on two consecutive weeks in rats, and such effects also occur via continuous intraperitoneal infusion by osmotic minipump into mice. However, Irinotecan (10 mg/kg) shows no effect on the growth of tumor by i.p[1]. Irinotecan (CPT-11, 100-300 mg/kg, i.p.) apparently suppresses tumor growth of HT-29 xenografts in athymic female mice by day 21. The two groups of Irinotecan (125 mg/kg) plus TSP-1 (10 mg/kg per day) or Irinotecan (150 mg/kg) in combination TSP-1 (20 mg/kg per day) are nearly equally effective and inhibit tumor growth 84% and 89%, respectively, and both are more effective than Irinotecan alone at doses of 250 and 300 mg/kg[3].

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