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10030-78-1 | 2-(Methylamino)-1H-purin-6(7H)-one

2-(Methylamino)-1H-purin-6(7H)-one NLT 98%

SKU : MC500535

CAS Number : 10030-78-1

Molecular Formula : C6H7N5O | Molecular Weight : 165.15

Synonyms : N2-methylguanine

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Purity NLT 98%
Storage at 20ºC 2 years
*The above information is for reference only.
Chemical Name 2-(Methylamino)-1H-purin-6(7H)-one
CAS Number 10030-78-1
Molecular Formula C6H7N5O
Molecular Weight 165.15
Synonyms N2-methylguanine
Introduction of 10030-78-1 :

2-(Methylamino)-1H-purin-6(7H)-one (N2-Methylguanine) is a modified nucleoside. 2-(Methylamino)-1H-purin-6(7H)-one is an endogenous methylated nucleoside found in human fluids. In Vitro: 2-(Methylamino)-1H-purin-6(7H)-one (N2-methylguanine) is found within both helical and looped regions of RNA secondary structure, and it can exist in either the s-cis or the s-trans rotamer. If there is a rotational preference for the methyl group, the effect of 2-(Methylamino)-1H-purin-6(7H)-one substitution may be specific to the sequence context depending upon which face of the base participates in hydrogen bonding[1]. 2-(Methylamino)-1H-purin-6(7H)-one (N2-methylguanine) is the principal kinetic barrier for reverse transcription in the 1340 bases proximal to the 5' end of E. coli 16S rRNA. Transcription intermediates correspond to attenuation at the positions of 2-(Methylamino)-1H-purin-6(7H)-one in the rRNA sequence. The relaxation time for elongation of the cDNA through m2G is approximately 3 min[2].

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