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100403-19-8 | Ceramide 3

Ceramide 3 NLT 98%

SKU : MC500655

CAS Number : 100403-19-8

Molecular Formula : C36H71NO4 | Molecular Weight : 581.95

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Purity NLT 98%
Storage at 20ºC 2 years
*The above information is for reference only.
Chemical Name Ceramide 3
CAS Number 100403-19-8
Molecular Formula C36H71NO4
Molecular Weight 581.95
Introduction of 100403-19-8 :

Ceramides Mixture is an endogenous ceramide and consists of hydroxy and non-hydroxy fatty acid-containing ceramides. Ceramides Mixture is a main lipid component of the permeability barrier in epidermis. Ceramides Mixture is involved in the regulation of growth inhibition, cell cycle arrest, and modulation of telomerase activity[1][2]. In Vitro: Endogenous Ceramides (generated in response to bacterial sphingomyelinase overexpression or daunorubicin treatment) inhibits mRNA synthesis of telomerase reverse transcriptase and telomerase activity via inactivation of c-Myc transcription factor in the A549 human lung adenocarcinoma cell line[1].
The sustained generation of long chain endogenous ceramide requires the biochemical recycling of the sphingosine backbone of C6-ceramide, which involves deacylation and reacylation of ceramide for the generation of endogenous long chain ceramide (mainly C16:0- and C24:1-Ceramides), most likely by CoA-dependent ceramide synthase, which is inhibited by fumonisin B1. In A549 cells the generation of long chain endogenous ceramide mediates the effects of exogenous C6-ceramide on growth inhibition, cell cycle arrest, and the modulation of telomerase activity[1].

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