SKU : MC500700
CAS Number : 1004551-41-0
Molecular Formula : C36H37N5O4 | Molecular Weight : 603.71Quote Request
|Storage||at 20ºC 2 years|
* The above information is for reference only.
* If the product has intellectual property rights, a license granted is must or contact us.
BMS-654457 is a small-molecule, reversible inhibitor of factor XIa (FXIa), binding with human and rabbit FXIa with Kis of 0.2 and 0.42 nM, respectively. In Vitro: BMS-654457 shows comparable in vitro potency against FXIa in humans (Ki=0.2 nM) and in rabbits (Ki =0.42 nM), and was over 500-fold selective against coagulation-related proteases (thrombin, FXa and FVIIa) in these species. In Vivo: BMS-654457 is effective in the prevention of arterial thrombosis in rabbits with limited effects on bleeding time. BMS-654457 is a promising antithrombotic therapy with a wide therapeutic window.
© Copyright 2015-2023 Hangzhou MolCore BioPharmatech Co.,Ltd. All rights reserved.