SKU : MC500824
CAS Number : 1005264-47-0
Molecular Formula : C27H26N2O4S | Molecular Weight : 474.57
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
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Chemical Name | MX69 |
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CAS Number | 1005264-47-0 |
Molecular Formula | C27H26N2O4S |
Molecular Weight | 474.57 |
MX69 is an inhibitor of MDM2/XIAP, used for cancer treatment. In Vitro: MX69 blocks the MDM2 protein-XIAP RNA interaction, leading to MDM2 degradation. MX69 shows minimal inhibitory effect on normal human hematopoiesis in vitro and is very well tolerated in animal models. MX69-induced MDM2 downregulation results not only in inhibition of XIAP expression, but also in activation of p53, which contributes to cancer cell apoptosis in vitro[1]. In Vivo: MX69-induced MDM2 downregulation results in activation of p53 which contributes to inhibition of cancer cell proliferation in vivo[1].
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