SKU : MC500835
CAS Number : 1005334-57-5
Molecular Formula : C24H19NO7S | Molecular Weight : 465.48Quote Request
|Storage||at 20ºC 2 years|
* The above information is for reference only.
* If the product has intellectual property rights, a license granted is must or contact us.
CVT-10216 is a highly selective, reversible aldehyde dehydrogenase-2 (ALDH-2) inhibitor with an IC50 of 29 nM. CVT-10216 also has inhibitory effect of ALDH-1 with an IC50 of 1.3 μM. CVT-10216 can reduce excessive alcohol drinking in alcohol-preferring rats and exhibit anxiolytic effects. IC50 & Target: IC50: 29 nM (ALDH-2) In Vivo: CVT-10216 (intraperitoneal injection; 3.75, 7.5, or 15 mg/kg) exhibits a increase in social interaction as a dose-dependent manner, punctuated by a 2-fold increase in social interaction after 15 mg/kg in Fawn-Hooded rats.
CVT-10216 (intraperitoneal injection; 3.75 or 15 mg/kg) are determined 5 h into the third withdrawal.It has the anxiolytic effect of 15 mg/kg CVT-10216 in this model, but has no significant effects on locomotor activity.
© Copyright 2015-2023 Hangzhou MolCore BioPharmatech Co.,Ltd. All rights reserved.