Tel: +86 (0)571 8102-5280 Email: sales@molcore.com
1005334-57-5 | CVT-10216

CVT-10216 NLT 98%

SKU : MC500835

CAS Number : 1005334-57-5

Molecular Formula : C24H19NO7S | Molecular Weight : 465.48

Quote Request
Purity NLT 98%
Storage at 20ºC 2 years
*The above information is for reference only.
Chemical Name CVT-10216
CAS Number 1005334-57-5
Molecular Formula C24H19NO7S
Molecular Weight 465.48
Introduction of 1005334-57-5 :

CVT-10216 is a highly selective, reversible aldehyde dehydrogenase-2 (ALDH-2) inhibitor with an IC50 of 29 nM. CVT-10216 also has inhibitory effect of ALDH-1 with an IC50 of 1.3 μM. CVT-10216 can reduce excessive alcohol drinking in alcohol-preferring rats and exhibit anxiolytic effects[1]. IC50 & Target: IC50: 29 nM (ALDH-2)[1] In Vivo: CVT-10216 (intraperitoneal injection; 3.75, 7.5, or 15 mg/kg) exhibits a increase in social interaction as a dose-dependent manner, punctuated by a 2-fold increase in social interaction after 15 mg/kg in Fawn-Hooded rats[1].
CVT-10216 (intraperitoneal injection; 3.75 or 15 mg/kg) are determined 5 h into the third withdrawal.It has the anxiolytic effect of 15 mg/kg CVT-10216 in this model, but has no significant effects on locomotor activity[1].

Related Products