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1005775-56-3 | TC ASK 10

TC ASK 10 NLT 98%

SKU : MC500877

CAS Number : 1005775-56-3

Molecular Formula : C21H23Cl2N5O | Molecular Weight : 432.35

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Purity NLT 98%
Storage at 20ºC 2 years
*The above information is for reference only.
Chemical Name TC ASK 10
CAS Number 1005775-56-3
Molecular Formula C21H23Cl2N5O
Molecular Weight 432.35
Introduction of 1005775-56-3 :

TC ASK 10 (Compound 10) is a potent, selective and orally active apoptosis signal-regulating kinase 1 (ASK1) inhibitor with an IC50 of 14 nM. The inhibitory activities of TC ASK 10 towards other representative panel of kinases are less than 50%, except for ASK2 (IC50 of 0.51 μM)[1]. In Vitro: TC ASK 10 (Compound 10; 0-10 μM; 1 hour; INS-1 cells) treatment inhibits streptozotocin (STZ)-induced JNK in INS-1 pancreatic β cells from 0.3 μM. Phosphorylation of p38 is also inhibited in a dosedependent manner[1]. In Vivo: Pharmacokinetic profiles in rats are tested. TC ASK 10 (Compound 10•HCl; rat cassette doing at 0.1 mg/kg, iv and 1 mg/kg, po.) has a good oral bioavailability. The Cmax, Tmax and AUCpo,0-8h are 285.1 ng/mL, 1.67 h and 275.4 ng.h/mL, respectively for TC ASK 10[1].

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