Product Number : MC500933
CAS Number : 1006378-90-0
Molecular Formula : C21H14F2N2O | Molecular Weight : 348.35
Quote RequestPurity | NLT 98% |
---|---|
Storage | at 20ºC 2 years |
MolCore specializes in manufacturing high-purity CAS No.1006378-90-0, p38 MAPK-IN-1 with the molecular formula C21H14F2N2O and molecular weight 348.35 delivering critical API intermediates for global pharmaceutical and research industries, certified under ISO quality systems. |
* The above information is for reference only.
Chemical Name | p38 MAPK-IN-1 |
---|---|
CAS Number | 1006378-90-0 |
Molecular Formula | C21H14F2N2O |
Molecular Weight | 348.35 |
p38 MAPK-IN-1 (Compound 4) is a novel potent and selective inhibitor of p38 MAPK with IC50 of 68 nM. p38 MAPK-IN-1 shows sustained levels, low clearance and good bioavailability. In Vivo: p38 MAPK-IN-1 (Compound 4; 1 mg/kg for iv and 10 mg/kg for po) has a t1/2 of 7.4 hours and CL of 2.7 mL/min/kg for iv, and a Cmax of 5.3 μM for po in male wistar rats[1].
p38 MAPK-IN-1 dose-dependently inhibits TNFα production with an ED50 of 0.5 mg/kg[1].
© Copyright 2015-2025 Hangzhou MolCore BioPharmatech Co.,Ltd. All rights reserved.