SKU : MC501073
CAS Number : 1007392-69-9
Molecular Formula : C33H38Cl3N3O4 | Molecular Weight : 647.03
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
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Chemical Name | ACT 178882 |
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CAS Number | 1007392-69-9 |
Molecular Formula | C33H38Cl3N3O4 |
Molecular Weight | 647.03 |
ACT 178882 is a new Renin inhibitor with an IC50 of 1.4 nM. IC50 & Target: IC50: 1.4 nM (Renin)[1] In Vitro: The median time to Cmax (tmax) for ACT 178882 is prolonged from 3.5 to 5.0 h by diltiazem whereas its apparent terminal half-life (t½) is unaffected by diltiazem, 22.9 and 24.2 h for treatments A and B, respectively. Using treatment A as reference, the geometric mean ratio (90% CI) is 1.62 (1.36 to 1.94) for Cmax and 2.02 (1.75 to 2.34) for AUC∞, indicating a significant interaction between ACT 178882 and diltiazem[2].
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