ACT 178882 NLT 98%

ACT 178882 is a new Renin inhibitor with an IC₅₀ of 1.4 nM. IC50 & Target: IC50: 1.4 nM (Renin)^[1] In Vitro: The median time to C_max (t_max) for ACT 178882 is prolonged from 3.5 to 5.0 h by diltiazem whereas its apparent terminal half-life (t_½) is unaffected by diltiazem, 22.9 and 24.2 h for treatments A and B, respectively. Using treatment A as reference, the geometric mean ratio (90% CI) is 1.62 (1.36 to 1.94) for C_max and 2.02 (1.75 to 2.34) for AUC_∞, indicating a significant interaction between ACT 178882 and diltiazem^[2].