SKU : MC501204
CAS Number : 10083-24-6
Molecular Formula : C14H12O4 | Molecular Weight : 244.24
Synonyms : Astringenin;trans-Piceatannol
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
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Chemical Name | Piceatannol |
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CAS Number | 10083-24-6 |
MDL Number | MFCD00221715 |
Molecular Formula | C14H12O4 |
Molecular Weight | 244.24 |
Synonyms | Astringenin;trans-Piceatannol |
Piceatannol is a selective inhibitor of protein tyrosine kinase Syk. It could inhibit ICa,L, Ito, IKr, Ca2+ transients and Na+-Ca2+ exchange except IK1. Shows multiple biological activities such as anti-inflammatory, antiproliferative and immunomodulatory effects. In vitro: The treatment of human myeloid cells with piceatannol suppressed TNF-induced DNA binding activity of NF-κB. The effect of piceatannol was not restricted to myeloid cells, as TNF-induced NF-κB activation was also suppressed in lymphocyte and epithelial cells. Piceatannol also inhibited NF-κB activated by H2O2, PMA, LPS, okadaic acid, and ceramide. [1]
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