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100872-83-1 | ML346

ML346 NLT 98%

SKU : MC501248

CAS Number : 100872-83-1

Molecular Formula : C14H12N2O4 | Molecular Weight : 272.26

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Purity NLT 98%
Storage at 20ºC 2 years
*The above information is for reference only.
Chemical Name ML346
CAS Number 100872-83-1
Molecular Formula C14H12N2O4
Molecular Weight 272.26
Introduction of 100872-83-1 :

ML346 is an activator of heat shock protein 70 (Hsp70), with an EC50 of 4600 nM in HeLa cells. IC50 & Target: EC50: 4600 nM (Hsp70, in HeLa cells)[1] In Vitro: ML346 is an activator of Hsp70, with an EC50 of 4600 nM in HeLa cells. ML346 (10 μM) restores proteostasis, restores CFTR-mediated iodide conductance, and enhances the correct folding of proteins expressed in two different cellular compartments[1]. ML346 (Compound F1) induces multiple responses and strongly induces Hsp70, the oxidative stress response genes (HO1 and GCLM), and a 2.5-fold upregulation of BiP in WT MEF cells. ML346 (0.5-25 μM) exhibits cytoprotective effects in cells after a 35 min severe heat shock, and also causes a two-fold protection from H2O2-induced apoptosis[2].

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